Human Cord Blood Mononuclear Cells – MNC

As the name implies, mononuclear cells (MNC) are blood cells that have a large single nucleus. In order of abundance, 40% are MNC lymphocytes, 30% are monocytes, 20% are various other white blood cells such as eosinophils and basophils, nucleated red blood cells are considered immediate progenitors of Red Blood Cells, and various stem cells, including CD34+ hematopoietic stem cells and vascular progenitor cells, CD133+ pluripotent stem cells, mesenchymal stem cells, fibroblasts, SSEA3+ pluripotent mesenchymal stem cells, and other cells. MNC is often used in the field of immunology, infectious disease, hematopoietic disease, vaccine development, transplant therapy and high-throughput screening. MNCs derived from umbilical cord blood is also used in research for nonhematopoietic degenerative condition, hereditary ataxia and spinal cord injury, etc.